Influence of Metal Nanoparticles on Blood Coagulation

Influence of Metal Nanoparticles

الملخص

Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The main aim of this research is to study the primary effects of silver nanoparticles (AgNPs) on haemostasis in vitro. Blood samples were obtained from Iraqi individuals (n=90) (32 females, 58 males; smokers 45 and non-smokers 45) aged between 25 to 65 years. The effect of AgNPs on blood coagulation was investigated directly estimating the activation of Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) and to verify any possible effect of AgNPs on human platelets.
In addition, the influence of various factors including health status, gender, and smoking activity on the values of PT and APTT levels in blood samples was also investigated. The results show that the values of PT and APTT were significantly increased by using 100 μg/ml of AgNPs. In contrast, there is no significant effect of health status, gender, and smoking activity on the level of PT and APTT at P = 0.05.
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