Unraveling MS Pathogenesis: The Critical Roles of B and T Cells in Disease Development
Department of Clinical Laboratory Sciences, college of pharmacy, university of Kerbala. Iraq. 2Department of pharmaceutical chemistry, college of pharmacy, university of Kerbala
الكلمات المفتاحية:
Multiple sclerosis pathogenesis، B cells، T cells، demyelination، autoimmuneالملخص
Abstract
Introduction
Multiple sclerosis is a complex inflammatory disease characterized by the immune system's aberrant attack on the central nervous system , leading to localized inflammation and demyelination of nerve cell sheaths. This autoimmune response is primarily mediated by lymphocytes, the body's defensive cells, which mistakenly target healthy central nervous system nerve cells, ultimately causing neurological impairments and a range of debilitating symptoms.
LiteratureReview
In recent years, extensive studies have explored the underlying mechanisms of Multiple sclerosis pathophysiology. Traditionally, T cells have been understood as central to MS progression, mediating immune-driven central nerve system damage. However, emerging research has uncovered an equally critical role for B cells, challenging the established paradigm and broadening the understanding of immune involvement in Multiple sclerosis. This review reevaluates past research and recent findings on the dual contributions of T and B cells to MS pathology, highlighting how B cells may drive disease progression through mechanisms distinct from those of T cells.
Conclusion
Current insights into Multiple sclerosis pathogenesis reveal a more complex immune network than previously thought, with both T and B cells contributing to central nerve system inflammation and demyelination. The recognition of B cells’ significant role, alongside T cells, offers new perspectives on therapeutic targets and suggests that effective MS treatments may require a multifaceted approach to immune modulation.
