Association between Anti-tissue Transglutaminase (Anti-tTG IgG and IgA ) , Circulating membrane attack complex (MC5b-9) and interleukins (IL17 and IL21) in Celiac Disease

Abstract

Celiac disease is triggered by gluten -derived peptide (e.g., gliadin ) in genetically susceptible HLA DQ2 and DQ8 histocompatibility antigen, and enteropathy. This study aimed to investigate the relationship Anti-tissue Transglutaminase (Anti-tTG IgA),Anti-tissue Transglutaminase (Anti-tTG IgG) with membrane attack complex (MC5b-) and IL-17 and IL-21.From 1st August to 1st January, 2024, this study was carried out at Marjan Hospital in the Babylon Governorate. This study concluded that anti- IgG and IgA concentrations increased gradually with marsh (0,1,2,3) were (12.77, 26.60, 39.45, 60.56/ 9.17,11.38,41.96, 64.7) respectively, while (MC5b-9) and . (IL-17) and IL-21 were high significantly increased with marsh 3 only . (430.50) (77.20, 217.64) respectively. This study concluded increased serum anti-tTG IgG , IgA with all marsh gradually and IL-17, IL-21 and MC5b-9 concentrations with Marsh 3.