the Levels of serum concentration adiponkines (ghrelin and obestatin) in patient with hypothyroidism

*Postgraduate student (MSc.) Department of Biology, College of science University of Kerbala, Hillah, Iraq **PhD. / Kerbala University, College of science, Department of Biology, Karbala, Iraq ***PhD. Biochemistry/ Kerbala University, Faculty of Medicine, Department of Biochemistry, Karbala, Iraq

Abstract

Background: Hypothyroidism is one of the most widespread disorders affecting the thyroid gland in the world, which associated with hormonal disorders. Objective: the aim of this study to measured adipokines (ghrelin and obestatin) in hypothyroidism patients.                                                                                                                            

Patient and method: A case-control study comprised 60 samples from hypothyroidism patients and 30 healthy samples from female patients ranging in age from 20 to 70 . A questionnaire was designed for collecting patiens as required in criteria of the study and to distinguish them from healthy controls. This questionnaire include Age, hight, weight, BMI, chronic disease and duration of illness for patients.                                                                                                                  A thorough clinical history, physical examination, and pertinent laboratory tests were performed on the patients, and an evaluation of laboratory measures for thyroid diseases was used to establish the kind of problem. Serum ghrelin and obestatin concentrations were measured in serum samples using the enzyme-linked immunosorbent assay system (ELISA) using the Competitive-ELISA method