Protective effect of active and nano-naringenin on methotrexate -induced oxidative stress in male rats’ reproductive system

Authors

  • Huda S. Shehab-ALdeen Al Bayati Directorate of education of kerbala, Ministry of Education,Iraq
  • Bushra Abbas Al Zubaidi Department of Biology, College of Education for Women, University of Kufa, Iraq

DOI:

https://doi.org/10.59658/jkas.v11i3.2344

Keywords:

methotrexate, Naringenin, active Naringenin ,nano-Naringenin, re-productive system, sex hormones

Abstract

In this study, which aimed to determine the preventive effect of Naringenin extracted from citrus aurantifolial on the damage caused by the methotrexate, in which 30 male rats were used, divided into five groups, which were control group dosed with Normal Saline (G1), second group dosed with methotrexate (G2) , third group dosed with Naringenin (15 to 15.5 mg) (G3), four group dosed with methotrexate  and active Naringenin (G4) , fifth group dosed with methotrexate and Naringenin nanoparticles (G5) for two months, it was found that significantly increase the level of sex hormones and sperm parameters in G3 , G5 compared to G2 . It was also found that active Naringenin , Naringenin nanoparticles works to repair damage to the tissues of the testicles, epididymis and accessory glands caused by methotrexate the experimental group administered with G3,G4 and G5 had a typical testicular tissue shape characterized by tubules. Spermatozoa exhibit an elliptical morphology and are organized in a systematic and orderly fashion. the basement membrane envelops each tubule and contains sperm-generating cells, including dispersed Sertoli cells with triangle nuclei sperm progenitors In conclusion, the results of this article revealed It was found that Naringenin alone and  Naringenin nanoparticles with the drug gave the best results on the methotrexate -induced male rats reproductive system

Downloads

Published

09/17/2024

How to Cite

Al Bayati, H. S. S.-A. ., & Al Zubaidi, B. A. . (2024). Protective effect of active and nano-naringenin on methotrexate -induced oxidative stress in male rats’ reproductive system. Journal of Kerbala for Agricultural Sciences, 11(3), 115–135. https://doi.org/10.59658/jkas.v11i3.2344

Issue

Vol. 11 No. 3 (2024): volume 11 issue 3 year 2024

Section

Articles

License

Copyright (c) 2024 Copyright (c) 2024 is the Author's article. Published by the Journal of Kerbala for Agricultural Sciences under a CC BY 4.0 license

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing Terms

All articles are published under a Creative Commons License and will be directed to the  Creative Commons Attribution 4.0 International License (CC BY 4.0) That permits use, distribution, and reproduction in any medium, provided the original work is properly cited. This license also allows the work to be used for commercial purposes.

Use by both non-commercial and commercial  users

This content is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) license, permitting use by both non-commercial and commercial users. Individual users may access, download, copy, display, and redistribute the articles to colleagues, as well as adapt, translate, and text- and data-mine the content, subject to the following conditions:

  • The author's moral rights, including the right of attribution and the right to protect their work from derogatory treatment, are respected.
  • Where content in the article is identified as belonging to a third party, users must ensure that any reuse complies with the copyright policies of the owner of that content.
  • If the article content is reused for research or educational purposes, users should maintain a link to the appropriate bibliographic citation, including the DOI and a link to the published version on the journal's website.