Histopathological effect of Conium maculatum aqueous extract on liver in Rats

Abstract

Conium maculatum is amongst the most poisonous species throughout higher plants. Humans and livestock are also both poisoned by Conium maculatum. Cosequently, Conium can be found growing alongside highways, purple-spotted, glabrous, and up to 3-meter-high , and branching. The leaves are decompounding pinnately like several edible and medicinal herbs. Coniine and -coniceine, two alkaloids found abundantly, are thought to be responsible for the plant's toxicity and teratogenicity, the relative ratio of distinct Conium alkaloids appears to be affected by several conditions such as temperature, hydration, period, and stage of growth. Conium includes piperidine alkaloids that are structurally similar to nicotine. They bind to nicotinic-type acetylcholine receptors and behave as agonists. The Rats  used in this study were all from the Animal Resource Center at the University of Kerbala's College of Veterinary Medicine. In the current experiment, several doses of aqueous extract of conium were used at concentrations of  2, 5  and 10 mg/kg to get whatever effect these may have on the liver in Rats. 24 mature rats were divided into 4 groups, six rats for each concentration and control as well. The results showed massive changes on the liver tissues for all groups in comparison  with control. However, all groups receiving Conium maculatum extract infusions at rates of 2 , 5 and 10 mg/kg of drinking aqueous revealed toxic changes in the liver in Rats, according to the findings of the research study