Association between Helicobacter pylori infection IgG and HbA1c in type 2 diabetes mellitus

Abstract

Abstract

Background: Infection with Helicobacter pylori has been recognized as a public health problem worldwide. Patients with diabetes mellitus are more liable to infection. The aim of the study was to determine the association between Helicobacter pylori IgGin type 2 diabetes mellitus in Erbil Cityand to find whether H. pyloriinfection associated with higher levels of glycated hemoglobin (HbA1c).

Materials and Methods: The study was a case-control study and carried out at Laila Kasim Health Centre. Around150 type 2 diabetes mellitus patients and 50 non-diabetic patients wererecruited. The study was conducted between September to November 2020.Blood sampleswere collectedand analyzed for blood sugar, HbA1c and serum used for detection of anti-Helicobacter pylori antibody (IgG) by ELISA.

Results:Helicobacterpylori infection was detected in 73.3% of Type 2 diabetes mellitus (T2DM) patients and54% of controls(P= 0.01). Helicobacter pyloriinfection was highly prevalent in patients with fair control of blood glucose (HbA1c 83.8%; P= 0.007).Helicobacterpylori infection was not associated with; duration of T2DM, age, gender, body mass index (BMI), alcohol consumption,dyspeptic symptoms and level of education.

Conclusion:

This study found that the prevalence of H. pylori infection among diabetic patients was significantly higherespecially in those with fair control of blood glucose. This indicates thatH. pyloriinfection could be a potential risk factor for Type 2 Diabetes Mellitus. 

Key word: Helicobacterpylori,Type 2 diabetesmellitus, HbA1c.